Sphingolipids from Bombycis Corpus 101A and their neurotrophic effects.

نویسندگان

  • Hak Cheol Kwon
  • Kang Choon Lee
  • Ock Ryun Cho
  • I Yeon Jung
  • Sae Yun Cho
  • Sun Yeou Kim
  • Kang Ro Lee
چکیده

Three new (2-4) and one known (1) sphingolipid were identified in the MeOH extract of Bombycis Corpus 101A. Their structures were elucidated as (4E,2S,3R)-2-N-octadecanoyl-4-tetradecasphingenine (1), (4E,6E,2S,3R)-2-N-eicosanoyl-4,6-tetradecasphingadienine (2), (4E,2S,3R)-2-N-eicosanoyl-4-tetradecasphingenine (3), and (4E,6E,2S,3R)-2-N-docosanoyl-4,6-tetradecasphingadienine (4) on the basis of spectroscopic data. Their neurotrophic effects were evaluated by examining PC12 cell neurite outgrowth.

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عنوان ژورنال:
  • Journal of natural products

دوره 66 4  شماره 

صفحات  -

تاریخ انتشار 2003